Enhanced Trellis Coded Multiple Access (ETCMA)

We propose an enhanced version of trellis coded multiple access (TCMA), an overloaded multiple access scheme that outperforms the original TCMA in terms of achieved spectral efficiency. Enhanced TCMA (ETCMA) performs simultaneous transmission of multiple data streams intended for users experiencing similar signal-to-noise ratios and can be employed both in the uplink and in the downlink of wireless systems, thus overcoming one of the main limitations of TCMA. Thanks to a new receiver algorithm, ETCMA is capable of delivering a significantly higher spectral efficiency. We show that ETCMA approaches the capacity of the Additive White Gaussian Noise channel for a wide range of signal-to-noise ratios.Comment: 5 pages, 5 figure

Permutation Polynomial Interleaved Zadoff-Chu Sequences

Constant amplitude zero autocorrelation (CAZAC) sequences have modulus one and ideal periodic autocorrelation function. Such sequences have been used in communications systems, e.g., for reference signals, synchronization signals and random access preambles. We propose a new family CAZAC sequences, which is constructed by interleaving a Zadoff-Chu sequence by a quadratic permutation polynomial (QPP), or by a permutation polynomial whose inverse is a QPP. It is demonstrated that a set of orthogonal interleaved Zadoff-Chu sequences can be constructed by proper choice of QPPs.Comment: Submitted to IEEE Transactions on Information Theor

C-class functions with new approach on coincidence point results for generalized (ψ,φ)-weakly contractions in ordered b-metric spaces

In this paper, by using the C-class functions and a new approach we present some coincidence point results for four mappings satisfying generalized (ψ,φ) -weakly contractive condition in the setting of ordered b-metric spaces. Also, an application and example are given to support our results.Scopu

Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Background: Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies. Methods: For this cross-sectional study, we assessed children and adolescents younger than 18 years with a clinical or genetic diagnosis of HeFH at the time of entry into the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry between Oct 1, 2015, and Jan 31, 2021. Data in the registry were collected from 55 regional or national registries in 48 countries. Diagnoses relying on self-reported history of familial hypercholesterolaemia and suspected secondary hypercholesterolaemia were excluded from the registry; people with untreated LDL cholesterol (LDL-C) of at least 13·0 mmol/L were excluded from this study. Data were assessed overall and by WHO region, World Bank country income status, age, diagnostic criteria, and index-case status. The main outcome of this study was to assess current identification and management of children and adolescents with familial hypercholesterolaemia. Findings: Of 63 093 individuals in the FHSC registry, 11 848 (18·8%) were children or adolescents younger than 18 years with HeFH and were included in this study; 5756 (50·2%) of 11 476 included individuals were female and 5720 (49·8%) were male. Sex data were missing for 372 (3·1%) of 11 848 individuals. Median age at registry entry was 9·6 years (IQR 5·8-13·2). 10 099 (89·9%) of 11 235 included individuals had a final genetically confirmed diagnosis of familial hypercholesterolaemia and 1136 (10·1%) had a clinical diagnosis. Genetically confirmed diagnosis data or clinical diagnosis data were missing for 613 (5·2%) of 11 848 individuals. Genetic diagnosis was more common in children and adolescents from high-income countries (9427 [92·4%] of 10 202) than in children and adolescents from non-high-income countries (199 [48·0%] of 415). 3414 (31·6%) of 10 804 children or adolescents were index cases. Familial-hypercholesterolaemia-related physical signs, cardiovascular risk factors, and cardiovascular disease were uncommon, but were more common in non-high-income countries. 7557 (72·4%) of 10 428 included children or adolescents were not taking lipid-lowering medication (LLM) and had a median LDL-C of 5·00 mmol/L (IQR 4·05-6·08). Compared with genetic diagnosis, the use of unadapted clinical criteria intended for use in adults and reliant on more extreme phenotypes could result in 50-75% of children and adolescents with familial hypercholesterolaemia not being identified. Interpretation: Clinical characteristics observed in adults with familial hypercholesterolaemia are uncommon in children and adolescents with familial hypercholesterolaemia, hence detection in this age group relies on measurement of LDL-C and genetic confirmation. Where genetic testing is unavailable, increased availability and use of LDL-C measurements in the first few years of life could help reduce the current gap between prevalence and detection, enabling increased use of combination LLM to reach recommended LDL-C targets early in life